Micky van de Ven Brace Ends The Toffees' Run at New Stadium
The Dutch defender emerged as the first backline player to score two goals in a English top-flight match for Spurs since Jan Vertonghen in March 2013.
Key points
The Spurs defender nods into the net two times in opening period
Everton's Jake O'Brien has goal ruled after VAR review
Senegalese midfielder nets third in 89th minute
The defeat is Everton's first at their new ground
Micky van de Ven found the net twice as Spurs extended their unbeaten run in away games in the top division and handed the Toffees their initial loss at Hill Dickinson Stadium.
The Toffees were unbeaten in their last five matches at their new ground at Bramley-Moore Dock, having left Goodison Park behind after 133 years at the end of last season.
But Tottenham's leader Van de Ven pounced twice from set-pieces in the first half to place their strong form at risk, and they were failed to turn it around before the midfielder - set up by former Toffees attacker Richarlison - headed home a third to put the game to bed.
The Everton defender believed he had equalized the scores a short while after Van de Ven's first goal, glancing a powerful header past Guglielmo Vicario from an Everton corner.
The Portuguese striker, in the meantime, missed a number of chances, while the Italian goalkeeper made a series of fine saves to guarantee Tottenham went five matches on the road without defeat in the Premier League.
But the video assistant referee stepped in, instructing Craig Pawson to check the score on the screen and the official ruled that Jack Grealish and Iliman Ndiaye were in an illegal position and had interfered with the Spurs keeper.
This victory moves Thomas Frank's side up to third in the Premier League, five points off north London rivals and leaders Arsenal.
Everton stay in 14th position and are six points ahead of the relegation zone.
Tottenham analysis: The defender fulfils duties at both ends of pitch
After a uninspiring weekday display in the European competition against Monaco, where they mustered a only attempts on goal, Frank chose the French striker up front instead of former Toffees player Richarlison.
The new arrival was unable to make much of an impact before being substituted for the substitute after an hour on the pitch, but it emerged he proved unnecessary in the final outcome.
Defender Van de Ven transformed into an offensive threat to be feared.
Spurs' opening strike came from a cleverly executed corner routine, with the midfielder heading the ball toward the six-yard box for an unmarked the defender to score.
And Ven de Ven - stepping up as skipper in the Argentine's unavailability - notched his next goal in added time as he outjumped Jordan Pickford to nod in.
Van de Ven was equally outstanding in defence, partnering effectively with his defensive colleague as the duo dealt excellently with the 34 crosses sent their way by Everton.
Toffees breakdown: Toffees lacking striker's instinct
The club's recent stadium had been a fortress, but it appears the novelty may have faded somewhat and fans flocked to the gates after Sarr's third for Spurs.
The break in Everton's winning streak at home will not be a major worry for David Moyes, but their attacking woes are.
The forward and Thierno Barry - the Everton's two recognised centre-forwards - had scored only a single goal between them before the weekend's match.
And they were failed to add to that miserable record on a wet and gloomy evening on Merseyside.
The striker's performance was summed up when he opted to overhead kick a clear chance from near the goal, despite having room and time to reposition for a simpler attempt that would have tested the keeper.
The substitute, too, failed to influence the game after replacing Beto in the 65th minute.
It was not for a lack of chance. The majority of the home side's attacks came through the winger and the forward, who relentlessly delivered threatening crosses into the Spurs box.
What next for both teams?
Everton: Moyes' men head to Sunderland in the top flight on Monday, 3 November at 8 PM.
Tottenham: Spurs go to Newcastle's ground on Wednesday, 29 October for their fourth-round Carabao Cup match against the Magpies.